Warning: Invalid argument supplied for foreach() in /home/customer/www/hk-pegasus.com/public_html/wp-content/plugins/happyforms/inc/classes/class-migrations.php on line 120
Pharma grade HPMC – Pegasus

Pharma grade HPMC

Hydroxypropyl methyl cellulose (HPMC; CAS No. 9004-65-3) is an odorless and tasteless, white to slightly off-white, fibrous or granular, free-flowing powder

Description

Hydroxypropyl methyl cellulose (HPMC; CAS No. 9004-65-3) is an odorless and tasteless, white to slightly off-white, fibrous or granular, free-flowing powder that is a synthetic modification of the natural polymer, cellulose.

Hydroxypropyl methyl cellulose has become one of the largest pharmaceutical excipients because it possesses the advantages of other complementary makings don’t have.

Advantages of HPMC

1. Chemical inertness

HPMC is a kind of non-ionic cellulose ether, whose solution doesn’t take ionic charge and don’t react with metal salt or ionic organics. So there is no reaction between it and other materials during the preparation.

2. Stability

it is relatively stable in acid and alkali, and providing good viscosity stability between pH3 ~ 11 during long-term storage. Aqueous solutions are comparatively enzyme-resistant. Preparation materials using HPMC, its quality and stability is better than the traditional materials (dextrin, starch, etc.).

3. Safety

HPMC is generally regarded as a nontoxic and non-irritating material, The WHO has not specified an acceptable daily intake for HPMC since the levels consumed were not considered to represent a hazard to health.

4. Viscosity can be regulatory

The derivatives of different viscosity of HPMC can complex with each other according to the different proportion. Its viscosity can be change according to certain rules, and has a good linear relationship, so it can be chosen accord- ing to requirements in terms of proportion.

5. Metabolism inertia

HPMC is not absorbed and metabolized in the body, and cannot give heat, so it is a safe medicinal preparation ma- terial.

6. Soluble in cold water

Soluble in cold water under 40 ℃ or 70% ethanol, practically insoluble in hot water but gelation.

Technical requirements

  1. Appearance:White to light yellow powder or grains.
  2. Specifications:

Table 1. Specifications of MC&HPMC

Items

Specifications

MC

HPMC

MA

F

E

J

K

Loss on drying,%

5.0 max

Residue on ignition,%

1.5 max

Heavy metals, ppm

20 max

Arsenic, ppm

3 max

pH

5.0~8.0

Viscosity(2% solution), mPa.s

In accordance with the viscosity specification as shown in table 2.

3. Viscosity specification

Table 2. Viscosity specification of MC&HPMC

Level

Specific range (2% Sol.),mPa.s

Level

Specific range (2% Sol.),mPa.s

5

4~6

4000

3000~5600

15

12~18

8000

6000~9000

25

20~30

10,000

9000~12000

50

40~60

15,000

12000~18000

100

80~120

20,000

18000~30000

400

300~500

40,000

30000~50000

800

600~900

100,000

85000~130000

1500

1000~2000

200,000

≥180000

NoteThe viscosity can be adjusted according to the special requirements of the customers.

Selection guide of products for pharmaceutical

UsageApplicable type of the productTypical Use Level
Bulk LaxativeMA-4000,K-4000,K-100,0003-30%
Creams, Gels, and OintmentsMA-4000,E-4000,F-4000,K-40001-5%
Ophthalmic PreparationsE-400001.-0.5%
Eye drops preparationsMA-4000, F-4000, K-40000.1-0.5%
Suspending agentMA-4000, E-4000, K-40001-2%
AntacidsMA-1500,MA-4000,E-4000,K-4000,K-15000,F-40001-2%
Tablets binderMA-15, E-5, F-50, K-1000.5-5%
Conventional Tablet CoatingE-5,E-150.5-5%
Conventional Wet GranulationE-5,E-152-6%
Controlled Release CoatingsE-5,E-153-20%
Tablet coatingsE-5, E-15, E-500.5-5%
Controlled Release Matrix TabletsK-100,000,K-15,000,K-4000,E-400020-55%

 

Packaging

The product is packed in polyethylene bag enclosed in composite fiberboard drum or paper bag. The net weight is 25 kg/drum or 25 kg/bag.

The product should be kept in the original bag and stored in the dry and clean place far away from the source of heat and not put together with other chemicals.

 


 

 

 

 

Reviews

There are no reviews yet.

Be the first to review “Pharma grade HPMC”